You might say Dr. Charles Lee created a synthetic bone graft substitute by accident.

In the early 2000s, Mariah Lichtenstern was an undergrad studying the rhetoric of narrative and image at UC Berkeley and starting a boutique production company in the Bay Area. That was when Napster was disrupting the music industry in a way that would leave it forever changed.

Around the world, 2.1 billion people lack safe drinking water at home. This Sacramento startup aims to make a difference. 

For almost a decade, David Sypnieski has been working in the ag-tech space, focusing on the production and processing levels of California’s food system. Six years ago, he noticed a major hole in the supply chain: Food companies and growers didn’t have solid, easy-to-access data to help them evolve with the times.

The most common reason people visit their doctor might surprise you. It’s not back problems, high blood pressure or diabetes. According to a 2013 survey by the Mayo Clinic, the No. 1 reason is skin disorders.

The opioid crisis was born in the late 1990s. Pharmaceutical companies said opioids — a class of drugs that produce pleasurable effects and relieve pain — weren’t addicting. Healthcare providers prescribed more of them. Twenty years later, we’re in the throes of an epidemic.

The big idea was garbage.

Frederick Janson was in the garage, taking the trash out of his first house in North Natomas. That was when he noticed how full the blue recycle bin was with plastic containers. He realized these recyclables he was paying somebody to take away could be used as building materials.

Inflatable Pubs can be rented for corporate events, weddings, birthday parties or any other type of festivity. Prices range from $400 to $600 per day with additional shipping fees for deliveries outside the region. Right now, Shenanigans has two inflatable pubs, imported straight from Ireland.

For sports fans, it’s not about wins and losses, but how you experience that game that counts. Brian Dombrowski learned this shooting videos for youth and high school sports events in the Bay Area. He was filming original content for coaches, but they weren’t the only ones interested in his footage.

Typically, fruit goes through many hands — farmer, packer, shipper, broker — before reaching the supermarket. Based in Lodi, Branch to Box focuses on cutting out the middlemen (hence the name) to provide the freshest possible fruit to offices.